Related Experiment Videos
Gonadal dysfunction in diabetic men with organic impotence.
The Journal of Clinical Endocrinology and Metabolism
|July 1, 1987
Summary
Diabetic men with organic impotence show pituitary-testicular dysfunction. Testosterone therapy improved sexual function in selected patients, suggesting gonadal dysfunction contributes to impotence in diabetes.
Area of Science:
- Endocrinology
- Urology
- Diabetology
Background:
- Erectile dysfunction is common in men with diabetes mellitus.
- Previous studies on gonadal function and impotence in diabetic men have produced inconsistent findings.
Purpose of the Study:
- To investigate pituitary-testicular function in impotent diabetic men.
- To determine the relationship between gonadal dysfunction and organic impotence in diabetes.
Main Methods:
- Studied 28 impotent diabetic men and 15 normal men.
- Assessed impotence using clinical history, nocturnal penile tumescence (NPT) testing, psychological testing, and penile vascular studies.
- Measured urinary luteinizing hormone (LH) and serum free testosterone levels.
Main Results:
- Impotent diabetic men exhibited diminished NPT parameters compared to controls.
- Diabetic men with primary organic impotence showed increased urinary LH and decreased serum free testosterone.
- Blood glucose control improvement did not enhance pituitary-testicular function or NPT.
- Parenteral testosterone administration improved NPT and sexual function in patients with primary organic impotence and no vascular disease.
Conclusions:
- Primary gonadal dysfunction may be linked to organic impotence in diabetic men.
- Androgen therapy can improve outcomes for selected patients with diabetic-related organic impotence.