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Area of Science:

  • Oncology
  • Medical Diagnostics
  • Health Services Research

Background:

  • Emerging blood-based multi-cancer early detection (MCED) tests offer potential for widespread cancer screening.
  • Little is known about US adults' preferences for these novel MCED tests.

Purpose of the Study:

  • To quantify preferences for blood-based MCED tests among US adults aged 50-80 years.
  • To identify key attributes influencing MCED test adoption.

Main Methods:

  • A discrete choice experiment (DCE) was conducted online with 1700 US adults (aged 50-80).
  • Participants evaluated MCED tests based on five attributes: true positives, false negatives, false positives, unknown cancer origin, and number of cancers detected.
  • Latent class multinomial logit models were used for data analysis.

Main Results:

  • Three distinct preference classes were identified.
  • Across all classes, higher accuracy (more true positives, fewer false negatives/positives) and detection of more cancer types were preferred.
  • 72% of participants preferred adding MCED tests to current screenings.

Conclusions:

  • The majority of older US adults favor MCED screening, with accuracy being a key factor.
  • A minority (16%) showed distinct preferences, particularly concerning test accuracy, and were less likely to opt-in.
  • Understanding these preferences is crucial for MCED test implementation.