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Updated: Sep 4, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Low morbidity and mortality with COVID-19 in sickle cell disease: A single center experience

Preethi Ramachandran1, Abhilash Perisetti2, Balachandar Kathirvelu3

  • 1Department of Hematology and Oncology Brookdale University Hospital and Medical Center Brooklyn New York.

Ejhaem
|July 18, 2022
PubMed

Insights

Sickle cell disease (SCD) patients with COVID-19 may not face severe outcomes as initially feared. This case series suggests SCD patients might have some protection against severe COVID-19 complications.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pulmonology

Background:

  • Sickle cell disease (SCD) patients have comorbidities increasing risks for severe COVID-19.
  • Overlapping symptoms between SCD and COVID-19 necessitate prompt testing.
  • The impact of COVID-19 on SCD patients' morbidity and mortality is not well-defined.

Purpose of the Study:

  • To investigate the clinical presentation and outcomes of hospitalized sickle cell disease patients with COVID-19.
  • To assess the risk of severe complications in SCD patients infected with SARS-CoV-2.

Main Methods:

  • A case series of nine hospitalized sickle cell disease patients diagnosed with COVID-19.
  • Data collected from March 18, 2020, to April 30, 2020, at a New York City tertiary medical center.

Main Results:

  • The study included nine SCD patients with COVID-19, with a mean age of 27.9 years.
  • Patients presented with symptoms 1-2 weeks after onset.
  • All nine patients recovered and were discharged home, suggesting a potentially lower risk of severe outcomes.

Conclusions:

  • Despite perceived high risk, sickle cell disease patients may exhibit unexpected resilience to severe COVID-19.
  • Further research is needed to understand the protective mechanisms and confirm these findings in a larger cohort.

Keywords:
anemiageneral hematologyhematological oncologyhemoglobin disorderssickle cell disease

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