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Updated: Sep 4, 2025

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A Ring Expansion Approach To N-oxy-2,5-diketopiperazines

Amy C Jackson1, James T Olsen1, Sasha Sundstrom1

  • 1Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76706.

Tetrahedron Letters
|July 18, 2022
PubMed
Summary

A new ring expansion method transforms tetramic acids into N-oxy-2,5-diketopiperazines (DKPs). This approach enables efficient, late-stage synthesis of the hydroxamic acid group, useful for creating N-oxy-2,5-DKP natural products.

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