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Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse

Minyang Fu1, Dandan Peng1, Tianxia Lan1

  • 1Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

Acta Pharmaceutica Sinica. B
|July 18, 2022
PubMed

Insights

Connective tissue growth factor (CTGF) regulates key cellular processes and is implicated in diseases like inflammation and cancer. Targeting CTGF shows therapeutic promise, with drugs in clinical trials for various conditions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Connective tissue growth factor (CTGF) is a key regulator of cellular functions including proliferation, differentiation, and adhesion.
  • CTGF plays a role in disease pathogenesis through its involvement in pathways like Hippo, p53, and NF-κB.
  • Dysregulation of CTGF is linked to inflammation, fibrosis, and cancer development.

Purpose of the Study:

  • To systematically review the cellular events regulated by CTGF.
  • To elucidate the relationship between CTGF and the pathogenesis of various diseases.
  • To highlight current research on CTGF as a therapeutic target in preclinical and clinical trials.

Main Methods:

  • Literature review of studies on CTGF's biological functions.
  • Analysis of CTGF's role in disease-related signaling pathways.
  • Summary of preclinical and clinical trial data for CTGF-targeting drugs.

Main Results:

  • CTGF regulates diverse cellular processes and is implicated in multiple disease pathways.
  • CTGF acts as a downstream effector in inflammation, fibrosis, and cancer.
  • Monoclonal antibodies FG3149 and FG3019 targeting CTGF show promising outcomes in trials.

Conclusions:

  • CTGF is a significant factor in cellular regulation and disease development.
  • Targeting CTGF presents a potential therapeutic strategy for various diseases.
  • Ongoing clinical and preclinical research supports CTGF as a viable therapeutic target.
Keywords:
CCN familyCCN2CTGFCancerFibrosisImmunotherapyTargeted therapyTherapeutic strategies

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