Targeted Intraoperative Radiotherapy (TARGIT-IORT) for Early-Stage Invasive Breast Cancer: A Single Institution...

Area of Science:

• Oncology
• Radiotherapy
• Surgical Oncology

Background:

• Invasive breast cancer management involves radiotherapy options.
• Targeted intraoperative radiotherapy (TARGIT-IORT) offers a single-session treatment approach.
• Patient selection for Accelerated Partial Breast Irradiation (APBI) is guided by consensus guidelines.

Purpose of the Study:

• To evaluate the safety and efficacy of TARGIT-IORT for invasive breast cancer.
• To assess patient suitability for TARGIT-IORT based on ASTRO APBI guidelines.
• To analyze changes in suitability classification from pre- to post-operative pathology.

Main Methods:

• Retrospective review of 237 patients treated with TARGIT-IORT.
• Assessment of pre- and post-operative clinicopathologic factors against ASTRO APBI guidelines.
• Kaplan-Meier analysis for survival and recurrence probabilities.

Main Results:

• 80.6% of patients were suitable for TARGIT-IORT preoperatively; suitability changed in 40% post-pathology.
• Higher preoperative lesion size and BMI ≥ 30 kg/m² predicted suitability changes.
• Low 3-year ipsilateral breast tumor recurrence (IBTR) rate of 2.1%, with 0.8% true local recurrences.

Conclusions:

• TARGIT-IORT demonstrates a low IBTR rate in appropriately selected invasive breast cancer patients.
• Pre- to postoperative suitability changes are common, necessitating improved preoperative risk stratification.
• Adjuvant therapy should be considered for patients deemed cautionary or unsuitable postoperatively.