Related Experiment Video
Updated: Sep 4, 2025

Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
Oscillatory Resonance and Dynamic Manifolds in Cortical Networks With Time Delay and Multiple External Stimuli
Abstract:
Rhythmic oscillation is crucial for information transmission and neural communication among different brain areas. Stochastic resonance (SR) can evoke different patterns of neural oscillation. However, the characteristics of network resonance and underlying dynamical mechanisms are still unclear. In this paper, a biological model of cortical network is established and its dynamical response to external periodic stimulation is investigated. We explore the oscillatory resonance of excitatory and inhibitory populations in cortical network. It is found that the intrinsic parameters of neural populations determine the extent of resonant activity, indicating that the firing rate exhibits coherent oscillation when the frequency of external stimulation is close to intrinsic frequency of neural population. In addition, the nonlinear dynamics of cortical network in oscillatory resonance can be represented by helical manifolds in low-dimensional state space. The geometry of neural manifolds reveals the periodic dynamics and state transition in oscillatory resonance. Moreover, time delay in chemical synapses can induce multiple resonances, which appear intermittently at integer multiples of the period of input signal. The dynamical response of neural population achieves maximal periodically, due to the transition of network states induced by time delay. Furthermore, mean-field theory is applied to analyze theoretical dynamic of cortical networks with time delay and demonstrate the effective transmission of stimulation information via oscillatory resonance in the brain. Consequently, the obtained results contribute to the improvement of neuromodulation for neurological disease from the viewpoint of the neural basis.
Related Concept Videos
Damped Oscillations
Although friction and other non-conservative...
Oscillations In An LC Circuit
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Propagation of Action Potentials
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Concept of Resonance and its Characteristics
Forced Oscillations

