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The protocol for assessing olfactory working memory capacity in mice.

Li-Xin Jiang^1,2,3, Geng-Di Huang^4,5, Hua-Li Wang^1,2,3

¹Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.

Brain and Behavior

|July 18, 2022

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This summary is machine-generated.

Researchers developed an olfactory working memory capacity (OWMC) task to measure memory in mice. Alzheimer

Area of Science:

Neuroscience
Animal Behavior
Cognitive Science

Background:

Working memory capacity (WMC) is crucial for cognitive function but challenging to measure in rodents.
Existing rodent memory tasks often do not assess memory capacity directly.
There is a need for reliable assays to evaluate WMC changes in animal models.

Purpose of the Study:

To develop and validate an olfactory working memory capacity (OWMC) paradigm for mice.
To assess WMC in 5×FAD mice, an Alzheimer's disease model.
To investigate the impact of Alzheimer's disease on working memory capacity.

Main Methods:

Developed a novel OWMC task involving odor discrimination and nonmatching-to-sample rules.
The task included phases for adaptation, training, rule learning (single and multiple odors), and capacity testing.

Keywords:

5×FAD mice odor working memory capacity

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Assessed 3-month-old 5×FAD mice and wild-type (WT) littermates.

Main Results:

5×FAD mice and WT mice showed similar performance in initial rule-learning phases.
WMC was significantly reduced in 5×FAD mice compared to WT mice during capacity testing.
5×FAD mice made more errors than WT mice as memory load increased.

Conclusions:

The OWMC task is a sensitive and robust behavioral assay for measuring WMC in mice.
This paradigm reliably assesses WMC and its components in rodent models.
The study demonstrates impaired WMC in a mouse model of Alzheimer's disease.