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Neonatal oropharyngeal infection by HPV in our area

Jesús Joaquín Hijona Elósegui1, María Soledad Sánchez Torices2, Ana Cristina Fernández Rísquez1

  • 1Servicio de Obstetricia y Ginecología, Hospital Universitario Materno-Infantil, Complejo Hospitalario de Jaén, Jaén, Spain.

Anales De Pediatria
|July 19, 2022
PubMed

Insights

Neonatal oropharyngeal infection by human papillomavirus (HPV) is common after vaginal birth but usually clears within two years. Transvaginal vertical transmission is the primary infection route, though persistent HPV carriage in infants requires further study.

Area of Science:

  • Virology
  • Neonatal Health
  • Public Health

Background:

  • Human papillomavirus (HPV) is primarily known as a sexually transmitted infection.
  • Newborns can acquire HPV during the perinatal period via incompletely understood mechanisms.

Purpose of the Study:

  • To investigate the frequency and mechanisms of neonatal oropharyngeal HPV infection.
  • To determine the persistence of HPV colonization in infants up to age two years.

Main Methods:

  • Prospective, observational study of vaginally born neonates with HPV-positive mothers.
  • Detection of HPV in amniotic fluid, cord blood, and neonatal oropharyngeal secretions.
  • Microbiological follow-up of colonized infants for 24 months.

Main Results:

  • Oropharyngeal HPV colonization prevalence at birth was 58.24%.
  • Over 24 months, 94.34% of infants cleared HPV, while 5.66% showed persistent colonization.

Conclusions:

  • Neonatal oropharyngeal HPV colonization is frequent but typically self-limiting.
  • Transvaginal intrapartum vertical transmission is the main route of neonatal HPV infection.
  • The clinical significance of persistent HPV carriage in neonates remains undetermined.
Abstract

Keywords:
Human papillomavirusOrofaringeOropharynxPerinatalTransmisión verticalVertical transmissionVirus del papiloma humano

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