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A Comparative Study on Intranasal Versus Intravenous Lorazepam in the Management of Acute Seizure in Children

Nandan Rudra1, Taraknath Ghosh2, Uttam Kumar Roy3

  • 1Kalna Subdivisional & Superspeciality Hospital, Purba Burdwan (West Bengal), India.

Folia Medica
|July 19, 2022
PubMed

Insights

Intranasal lorazepam is as effective and safe as intravenous lorazepam for treating acute childhood seizures. This study suggests intranasal lorazepam is a viable alternative for emergency seizure management in children.

Area of Science:

  • Pediatric Emergency Medicine
  • Clinical Pharmacology
  • Neurology

Background:

  • Acute seizures in children are medical emergencies often treated with benzodiazepines.
  • Intravenous lorazepam is a recommended first-line therapy, but intranasal administration lacks established guidelines in India.
  • Intranasal lorazepam offers potential advantages in ease of administration and home-based treatment initiation.

Purpose of the Study:

  • To compare the effectiveness and safety of intranasal versus intravenous lorazepam for acute seizures in children aged 5-12 years.
  • To evaluate intranasal lorazepam as a potential alternative to intravenous administration.

Main Methods:

  • An analytical observational cross-sectional study design was employed.
  • Patients with acute seizures received lorazepam via either the intravenous or intranasal route.
  • The formulation and dosage of lorazepam were consistent across both administration routes.

Main Results:

  • No statistically significant differences were observed in patient demographics (sex, age, weight) between the groups.
  • Seizure control within 10 minutes and persistent cessation of seizure activity were comparable between intranasal and intravenous lorazepam.
  • Safety parameters demonstrated no significant differences between the two administration routes.

Conclusions:

  • Intranasal lorazepam demonstrates comparable effectiveness and safety to intravenous lorazepam in managing acute childhood seizures.
  • Intranasal lorazepam presents a valuable alternative option for emergency seizure management in pediatric patients.
  • Further research may support broader adoption of intranasal lorazepam in clinical practice.
Abstract

Keywords:
childrenefficacyintranasalintravenouslorazepamseizure

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