Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption...

Area of Science:

• Analytical Chemistry
• Pharmaceutical Science
• Spectroscopy

Background:

• Aluminum ions (Al3+) are used in some immunobiological drugs.
• Accurate quantification of Al3+ is crucial for drug safety and efficacy.
• Existing methods may have limitations for specific applications.

Purpose of the Study:

• To develop and validate a quantitative determination method for Al3+ in immunobiological drugs.
• To establish the analytical performance of the proposed method.
• To provide an alternative analytical approach for quality control.

Main Methods:

• Atomic absorption spectroscopy with electrothermal atomization (ETAAS) was employed.
• Optimization of aluminum hydroxide gel preparation conditions was performed.
• Method validation included assessment of accuracy and precision.

Main Results:

• The analytical range for Al3+ was determined to be 10-50 µg/L.
• The method demonstrated acceptable accuracy and in-laboratory precision.
• Optimized conditions for aluminum hydroxide gel preparation were identified.

Conclusions:

• The developed ETAAS method is suitable for the quantitative determination of Al3+ in immunobiological drugs.
• This method serves as a viable alternative to existing techniques.
• The validated method supports robust quality control of pharmaceutical products.