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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Related Experiment Video

Updated: Sep 4, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Thrombus-associated microbiota in acute ischemic stroke patients.

Melanie Walker1, Carla Uranga2, Samuel Hs Levy1

  • 1Department of Neurological Surgery, University of Washington, Seattle, Washington, United States.

Surgical Neurology International
|July 20, 2022
PubMed
Summary

This study found diverse bacterial signatures, mainly from oral bacteria, in cerebral thrombi from stroke patients. This demonstrates the feasibility of analyzing thrombus DNA to understand stroke

Keywords:
MetagenomicsMicrobiotaStrokeThrombectomy

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Area of Science:

  • Microbiome research
  • Neurology
  • Genomics

Background:

  • Stroke is a major global cause of death and disability.
  • Emerging evidence links gut microbiota to stroke risk and outcomes.
  • Cerebral thrombi from endovascular thrombectomy offer a unique source to study bacterial influence on stroke.

Purpose of the Study:

  • To investigate the presence and types of bacteria within cerebral thrombi.
  • To establish the technical feasibility of using 16S rRNA metagenomic sequencing on arterial thrombi.
  • To explore the potential role of oral bacteria in stroke pathophysiology.

Main Methods:

  • Cerebral thrombi were collected from ischemic stroke patients undergoing thrombectomy.
  • DNA was extracted and subjected to 16S rRNA amplicon-based metagenomic sequencing.
  • Bacterial identification was confirmed using Sanger sequencing of isolated colonies.

Main Results:

  • A diverse range of bacterial signatures was detected in the analyzed thrombi.
  • The predominant bacterial signatures were of cariogenic (oral) origin.
  • The study confirmed the presence of bacteria within the cerebral arteries of stroke patients.

Conclusions:

  • Amplicon-based metagenomic sequencing of arterial thrombi is feasible for stroke research.
  • Preliminary findings suggest a potential link between oral bacteria and stroke.
  • Further research into thrombus genomics could reveal novel insights into stroke pathogenesis and treatment.