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Elevated D-dimer and Adverse In-hospital Outcomes in COVID-19 Patients and Synergism with Hyperglycemia

Haowei Li1, Shimin Chen1, Shengshu Wang1

  • 1Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, State Key Laboratory of Kidney Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China.

Infection and Drug Resistance
|July 20, 2022
PubMed

Insights

Elevated D-dimer levels increase the risk of adverse outcomes in COVID-19 patients. Hyperglycemia and high D-dimer show a combined effect on COVID-19 prognosis, independent of diabetes.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • COVID-19 is frequently associated with hypercoagulability, indicated by elevated D-dimer levels.
  • Hyperglycemia may contribute to thrombosis activation in COVID-19 patients.

Purpose of the Study:

  • To investigate the association between D-dimer levels and in-hospital outcomes in COVID-19 patients.
  • To evaluate the synergistic effect of elevated D-dimer and hyperglycemia on COVID-19 prognosis.

Main Methods:

  • A retrospective cohort study of 2467 COVID-19 inpatients.
  • Collected data on D-dimer, fasting blood glucose (FBG), and adverse in-hospital outcomes.
  • Utilized Cox proportional risk models to analyze associations and combined effects.

Main Results:

  • 44.6% of patients had high D-dimer (≥0.50 mg/L), associated with older age and higher FBG.
  • High D-dimer significantly increased the adjusted risk of adverse in-hospital outcomes (HR, 2.73).
  • Combined high FBG and D-dimer levels showed a substantially increased risk (HR, 5.72).

Conclusions:

  • High D-dimer levels are linked to increased risk of adverse in-hospital outcomes in COVID-19.
  • Elevated D-dimer and hyperglycemia exhibit a synergistic effect on COVID-19 prognosis.
  • This synergistic risk is independent of a patient's history of diabetes.
Abstract

Keywords:
COVID-19D-dimercohort studyhyperglycemiain-hospital outcomes

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