Role of Posttranslational Modifications of Proteins in Cardiovascular Disease
Yong-Ping Liu1, Tie-Ning Zhang1, Ri Wen1
1Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, Shenyang, China.
Insights
Posttranslational modifications (PTMs) are crucial for cardiovascular system function and disease. Understanding PTMs offers new therapeutic strategies for cardiovascular diseases (CVD).
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Cardiovascular disease (CVD) is a major global health issue with incompletely understood molecular mechanisms.
- Posttranslational modifications (PTMs) are increasingly recognized for their significant roles in various diseases, including CVD.
Purpose of the Study:
- To review recent advancements in understanding PTMs within the cardiovascular system.
- To highlight the importance of PTMs in both normal physiological and pathological states of the cardiovascular system.
- To explore the potential of PTMs as therapeutic targets for CVD.
Main Methods:
- This review synthesizes findings from recent in vivo and in vitro studies.
- Literature search focused on PTMs and their impact on cardiovascular health and disease.
- Analysis of how PTMs influence protein activity and expression in the cardiovascular system.
Main Results:
- PTMs significantly impact protein function and expression, playing key roles in cardiovascular physiology and pathology.
- Specific PTMs have been identified as critical in the development and progression of various CVDs.
- Research on PTMs provides a deeper understanding of CVD molecular mechanisms.
Conclusions:
- PTMs are vital regulators in the cardiovascular system and are implicated in cardiovascular disease.
- Targeting PTMs presents promising avenues for developing novel therapeutic strategies for CVD.
- Further research into PTMs is essential for advancing CVD treatment and management.
Abstract:
Cardiovascular disease (CVD) has become a leading cause of mortality and morbidity globally, making it an urgent concern. Although some studies have been performed on CVD, its molecular mechanism remains largely unknown for all types of CVD. However, recent in vivo and in vitro studies have successfully identified the important roles of posttranslational modifications (PTMs) in various diseases, including CVD. Protein modification, also known as PTMs, refers to the chemical modification of specific amino acid residues after protein biosynthesis, which is a key process that can influence the activity or expression level of proteins. Studies on PTMs have contributed directly to improving the therapeutic strategies for CVD. In this review, we examined recent progress on PTMs and highlighted their importance in both physiological and pathological conditions of the cardiovascular system. Overall, the findings of this review contribute to the understanding of PTMs and their potential roles in the treatment of CVD.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
02:04Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
01:26Protein Modifications in the RER
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
01:26Coronary Artery Disease II: Pathophysiology
01:27Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
01:26Atherosclerosis III: Management