Partial omentectomy maybe practicable for T3 or shallower gastric cancer patients

Area of Science:

• Oncology
• Surgical Oncology
• Gastrointestinal Surgery

Background:

• Total omentectomy is a common adjunct to gastrectomy for gastric cancer.
• The benefit of omentectomy in gastric cancer remains debated.
• Tumor deposits (TDs) in the omentum are a key area of investigation.

Purpose of the Study:

• To analyze the incidence and clinical significance of tumor deposits (TDs) in different anatomical subregions of the perigastric omentum.
• To evaluate the prognostic value of TDs in gastric cancer patients undergoing gastrectomy with total omentectomy.

Main Methods:

• Retrospective review of 1253 gastric cancer patients who underwent gastrectomy with total omentectomy.
• Examination of TDs in various anatomical subregions of the perigastric omentum.
• Correlation analysis of TD presence and location with clinicopathological factors and survival outcomes.

Main Results:

• Tumor deposit positivity was observed in 11.2% of patients.
• TDs in the greater and lesser curvature omentum were associated with adverse prognostic factors including lymphovascular invasion, advanced stage, and poorer survival.
• TDs in the greater curvature omentum conferred the worst prognosis, followed by the lesser curvature, with proximal greater curvature TDs being an independent prognostic factor.

Conclusions:

• Presence and location of tumor deposits in the omentum significantly impact gastric cancer patient prognosis.
• TDs in the greater curvature omentum are associated with the worst outcomes.
• Partial omentectomy may be a viable option for patients with T3 or shallower gastric tumors.