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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
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Related Experiment Video

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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No exaggerated tremor severity perception in functional tremor.

Anne-Catherine M L Huys1, Patrick Haggard2, Kailash P Bhatia3

  • 1Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, 33 Queen Square, London, WC1N 3BG, UK. anne-catherine.huys.15@alumni.ucl.ac.uk.

Journal of Neurology
|July 20, 2022
PubMed
Summary

People with functional tremor do not exaggerate their symptoms. This study found no difference in subjective versus objective tremor severity, suggesting attention, not exaggeration, explains symptom changes.

Keywords:
AttentionExaggerationFunctional movement disordersFunctional neurological disorderPerceptionPrejudiceVisual feedback

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Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Functional neurological disorder (FND) symptoms are often perceived as constant and severe, sometimes leading to interpretations of exaggeration or fabrication.
  • This perception can be influenced by symptom reporting and clinical examination dynamics.

Purpose of the Study:

  • To investigate the accuracy of symptom perception and reporting in functional tremor.
  • To directly compare subjective and objective measures of tremor severity in FND, organic tremor, and healthy controls.

Main Methods:

  • Direct comparison of subjective and objective tremulousness during reaching movements.
  • Inclusion of participants with functional action tremor, organic action tremor, and healthy controls.
  • Utilized identical measures for subjective and objective assessments, including real-time perceptual tasks and retrospective reports.

Main Results:

  • No significant differences were found between subjective and objective tremor severity in any group (functional tremor, organic tremor, controls).
  • This held true for both immediate (real-time) and near-time (retrospective) reporting conditions.

Conclusions:

  • Individuals with functional tremor do not perceive or report their tremor with exaggeration compared to organic tremor or healthy individuals.
  • Attentional mechanisms, rather than symptom exaggeration, are proposed as a more plausible explanation for symptom exacerbation in FND.