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Microrobotic swarms for selective embolization.

Junhui Law1,2,3, Xian Wang1,4,5, Mengxi Luo1

  • 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.

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Area of Science:

  • Biomedical Engineering
  • Robotics
  • Medical Devices

Background:

  • Microrobotic swarms are inspired by natural systems for applications like drug delivery and imaging.
  • Current embolization techniques lack selectivity, leading to potential complications such as stroke and blindness.

Purpose of the Study:

  • To develop microrobotic swarms for selective embolization of blood vessels.
  • To address the limitations of existing embolization methods by enhancing precision and reducing risks.

Main Methods:

  • Formation of magnetic particle swarms for targeted embolization.
  • Establishment of an analytical model linking fluid dynamics and magnetic fields to swarm integrity.
  • Development of an actuation strategy to maintain swarm integrity under flow conditions.

Main Results:

  • Experimental validation in microfluidic channels, ex vivo tissues, and in vivo porcine kidneys.
  • Demonstration of the proposed strategy's efficacy in achieving selective embolization.
  • Confirmation of maintained swarm integrity within targeted regions.

Conclusions:

  • The developed magnetic microrobotic swarm strategy enables selective embolization.
  • This approach offers a promising solution to improve the safety and efficacy of embolization procedures.
  • Potential to reduce complications associated with current embolization techniques.