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Haematological manifestations in primary hyperparathyroidism.
1Department of Internal Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
The Indian Journal of Medical Research
|July 21, 2022
Summary
Primary hyperparathyroidism (PHPT) can cause anemia, leucopenia, and thrombocytopenia in patients with normal kidney function. Surgical treatment for parathyroid adenomas often leads to recovery from these hematological issues.
Area of Science:
- Endocrinology
- Hematology
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by elevated parathormone (PTH) secretion.
- PHPT can affect various bodily systems, including hematological parameters.
Purpose of the Study:
- To evaluate the hematological manifestations in patients with PHPT and normal renal function.
- To assess the impact of parathyroidectomy on these hematological changes.
Main Methods:
- A retrospective cross-sectional study included 134 patients undergoing parathyroidectomy for PHPT.
- Hematological parameters were analyzed in relation to calcium levels and post-surgery outcomes.
Main Results:
- The prevalence of anemia, leucopenia, and thrombocytopenia was 20.1%, 6.7%, and 6.0%, respectively.
- No significant correlation was found between PTH levels and hematological parameters.
- Significant recovery rates were observed 6-12 months post-parathyroidectomy for anemia (35.7%), leucopenia (85.7%), and thrombocytopenia (100%).
Conclusions:
- Anemia occurs in PHPT patients with normal renal function, independent of PTH or calcium levels.
- Parathyroidectomy shows a strong association with the resolution of leucopenia and thrombocytopenia in PHPT patients.
Keywords:
Anaemiahaematological manifestations of systemic diseasesleucopeniaprimary hyperparathyroidismthrombocytopeniaMore Related Videos
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