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Cyclophilin D: Guardian or Executioner for Tumor Cells?
Ling Zhang1, Yi Liu1,2, Rou Zhou3
1School of Nursing, Jining Medical University, Jining, China.
Frontiers in Oncology
|July 21, 2022
Summary
Cyclophilin D (CypD) impacts tumor progression, promoting aerobic glycolysis but showing controversial effects on malignant traits like survival and invasion. This review explores CypD's dual role in cancer.
Area of Science:
- Mitochondrial biology
- Cancer research
- Biochemistry
Background:
- Cyclophilin D (CypD) is a mitochondrial matrix enzyme with peptide-proline cis-trans isomerase (PPIase) activity.
- CypD regulates mitochondrial permeability transition pore (mPTP) opening and cellular bioenergetics.
- Initially studied for its role in cell death, CypD's function in tumors is now debated.
Purpose of the Study:
- To review the biological functions of Cyclophilin D (CypD).
- To elucidate the relationship between CypD and tumor progression.
- To focus on the controversial and dual role of CypD in various cancers.
Main Methods:
- Literature review of recent studies on CypD and cancer.
- Analysis of CypD's impact on tumor cell aerobic glycolysis.
- Examination of conflicting data regarding CypD's influence on tumor survival, invasion, and drug resistance.
Main Results:
- CypD promotes aerobic glycolysis in tumor cells.
- CypD's role in tumor cell survival, invasion, and drug resistance remains controversial.
- Evidence suggests a dual role for CypD in tumor progression.
Conclusions:
- Cyclophilin D exhibits complex functions in cancer.
- Understanding CypD's dual role is crucial for cancer therapy development.
- Further research is needed to clarify CypD's precise impact on malignant characteristics.
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