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Targeting CD47 as a Novel Immunotherapy for Breast Cancer

Can Chen1, Runlu Wang2, Xi Chen3

  • 1Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Frontiers in Oncology
|July 21, 2022
PubMed

Insights

CD47 blockade is a promising immune therapy for breast cancer, showing potential in preclinical and clinical studies. This review explores CD47

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Breast cancer is the most prevalent cancer globally, associated with significant mortality.
  • Immune checkpoint blockade offers a promising avenue for targeted cancer therapy.

Purpose of the Study:

  • To review therapeutic mechanisms targeting CD47 in breast cancer.
  • To evaluate the prognostic role and therapeutic value of CD47 in breast cancer.

Main Methods:

  • Literature review of preclinical studies.
  • Analysis of clinical trial data.
  • Summary of therapeutic strategies targeting CD47.

Main Results:

  • CD47 blockade is being investigated for its safety and efficacy in breast cancer.
  • Various therapeutic mechanisms targeting CD47 are under study.
  • CD47 plays a role in the prognosis and treatment of breast cancer.

Conclusions:

  • CD47 blockade represents a potential immunotherapy for breast cancer.
  • Further research is warranted to fully elucidate CD47's therapeutic value.
Keywords:
CD47SIRPαbreast cancerimmune checkpoint inhibitorsimmunotherapy

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