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Updated: Sep 4, 2025
Biofunctionalization of Magnetic Nanomaterials
Published on: July 16, 2020
Potential of novel self-assembled functionalized carbon nanotubes for selective tumor targeting
Chetan D Sabanis1, Bharathi R Kannan1, Ramesh Joga1
1Department of Regulatory Affairs, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Telangana, 500 037, India.
Abstract:
Conventional cancer therapies are associated with toxicity toward healthy cells, which need to be addressed by novel therapeutic approaches. US2021/0230592 patent application discloses a carbon nanotube-based approach for tumor targeting, wherein a self-assembling single-wall nanotube complex has been developed and functionalized to deliver a molecule to a cancerous cell. The radiolabeled nanotubes exhibited markedly reduced toxicity as they did not depict any 'over toxicity' up to radioactivity value of 1350 nCi. The single-wall carbon nanotube conjugates were covalently connected to several chelators, therapeutic or diagnostic radionuclides, and showed promising results in the effective cancer management. Besides, this invention with further modifications paves an ideal pathway to researchers in effective diagnosis and treatment of cancer.
Insights
This patent application introduces novel carbon nanotube (CNT) complexes for targeted cancer therapy. These functionalized CNTs show reduced toxicity and promise effective cancer diagnosis and treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Conventional cancer treatments often harm healthy cells, necessitating advanced therapeutic strategies.
- Targeted drug delivery systems are crucial for improving cancer treatment efficacy and reducing side effects.
Purpose of the Study:
- To present a novel carbon nanotube (CNT)-based platform for targeted tumor delivery.
- To demonstrate the potential of functionalized CNTs for cancer diagnosis and treatment.
Main Methods:
- Development of self-assembling single-wall carbon nanotube (SWCNT) complexes.
- Functionalization of SWCNTs for molecule delivery to cancerous cells.
- Radiolabeling of SWCNT conjugates with therapeutic or diagnostic radionuclides.
Main Results:
- SWCNT complexes showed reduced toxicity, with no "over toxicity" observed up to 1350 nCi.
- Covalently linked chelators, therapeutic, or diagnostic radionuclides to SWCNT conjugates.
- Promising results in effective cancer management were observed.
Conclusions:
- The developed SWCNT-based approach offers a promising strategy for targeted cancer therapy.
- This invention provides a foundation for advanced cancer diagnosis and treatment methods.
