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Updated: Sep 4, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Tailoring diradicaloid properties of expanded isophlorinoids with systematic core-modification
Madan D Ambhore1, Pragati Shukla1, Rajesh G Gonnade2
1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, 411008, Maharashtra, India. vg.anand@iiserpune.ac.in.
Abstract:
Herein, we describe the synthesis, structural diversity and diradicaloid characteristics of 38π core-modified aromatic expanded isophlorins with eight heterocyclic rings. The diradicaloid character of expanded isophlorinoid macrocycles was engineered by systematic structural modification. Depending on the nature of the link between the heteroatoms, they adopt planar and non-planar conformations. This large structural variation with a significant difference in the extent of aromaticity is correlated with the magnitude of their respective diradical character.
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