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Tunable elastomer materials with vascular tissue-like rupture mechanics behavior.

Andrea Corti1, Tariq Shameen1, Shivang Sharma1

  • 1City College of the City University of New York, Department of Biomedical Engineering, New York, NY 10029, United States of America.

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Three silicone materials were tested for replicating human artery mechanics. Sylgard170 and DowsilEE-3200 show promise for vascular tissue models due to their mechanical properties and rupture behavior.

Keywords:
dowsillaboratory modelsmock vesselssylgardultimate tensile stressuniaxial tensile testing

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Area of Science:

  • Biomaterials Science
  • Mechanical Engineering
  • Cardiovascular Research

Background:

  • Laboratory models are crucial for studying the mechanical behavior of human arteries.
  • Understanding vascular tissue mechanics aids in developing better medical devices and treatments.

Purpose of the Study:

  • To evaluate three silicone-based materials (Sylgard184, Sylgard170, DowsilEE-3200) as potential substitutes for human arterial tissues.
  • To characterize the mechanical properties and hyperelastic behavior of these silicones under various curing conditions.

Main Methods:

  • Uniaxial tensile tests were conducted on silicone samples to determine their stress-strain behavior and Poisson's ratios using digital image correlation (DIC).
  • Constitutive parameters for the 3-term Ogden model were derived for each material.
  • Numerical simulations of tubular models were performed under physiological radial pressure.

Main Results:

  • All tested silicones exhibited non-linear hyperelasticity, with properties varying based on curing conditions.
  • Sylgard184 was the stiffest material, while Sylgard170 and DowsilEE-3200 demonstrated mechanical properties closer to reported values for arterial tissues.
  • Circumferential stresses in numerical models were comparable to those in human common carotid arteries.

Conclusions:

  • Sylgard170 and DowsilEE-3200 are suitable candidates for replicating vascular tissue rupture behavior in laboratory settings.
  • These materials can be effectively used in cylindrical laboratory models subjected to physiological and supra-physiological loading conditions.