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Brain Metastasis from Pancreatic Cancer: Our Experience and Systematic Review
Frank A De Stefano1, Alexis Morell2, Katya Marks3
1Department of Neurological Surgery, University of Kansas, Kansas City, Kansas, USA.
World Neurosurgery
|July 21, 2022
Summary
Brain metastasis from pancreatic cancer is rare but neurosurgical intervention may improve survival. Our institutional data showed significantly better outcomes than existing literature, suggesting personalized treatment may enhance prognosis.
Area of Science:
- Neurosurgery
- Oncology
- Gastroenterology
Background:
- Pancreatic cancer rarely metastasizes to the brain.
- Brain metastases from pancreatic cancer are associated with poor prognosis.
Purpose of the Study:
- To review neurosurgical management and outcomes of pancreatic brain metastases.
- To compare literature data with institutional experience.
Main Methods:
- Systematic literature review following PRISMA guidelines (PubMed, Embase, Scopus, Web of Science).
- Retrospective analysis of patients treated at a single institution.
Main Results:
- 17 studies (23 patients) identified in literature review.
- Median survival after brain metastasis diagnosis: 3 months (literature) vs. 30.5 months (institutional).
- Institutional cohort showed significantly prolonged survival (P=0.03).
Conclusions:
- Pancreatic brain metastases are rare and typically fatal.
- Patient-specific and treatment factors may indicate better prognosis.
- Further research needed for multimodal therapy and personalized decision-making.
