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Related Concept Videos

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Updated: Sep 4, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Neonatal infections: Insights from a multicenter longitudinal research collaborative.

Dustin D Flannery1, Karen M Puopolo1, Nellie I Hansen2

  • 1Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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Summary

The Neonatal Research Network (NRN) has studied neonatal infections for over 30 years, providing crucial data for clinical practice and national guidelines. Their research informs infection risk assessment, diagnosis, and treatment strategies.

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Area of Science:

  • Neonatal research
  • Infectious disease epidemiology
  • Clinical neonatology

Background:

  • The Neonatal Research Network (NRN) has a long-standing commitment to investigating neonatal infections.
  • Decades of research have addressed incidence, microbiology, risk factors, and outcomes of these infections.
  • NRN studies have significantly influenced clinical practice and policy regarding neonatal infections.

Purpose of the Study:

  • To summarize key findings from NRN infection-related studies.
  • To highlight research published from 2000 onwards.
  • To underscore the network's contribution to understanding and managing neonatal infections.

Main Methods:

  • Review of NRN-conducted studies on neonatal infections.
  • Focus on epidemiological data, including incidence and microbiology.
  • Analysis of maternal and neonatal risk factors, clinical findings, and outcomes.

Main Results:

  • NRN studies have provided critical data for infection risk assessment and national guidance.
  • Research has spurred advancements in infection diagnosis and treatment protocols.
  • Antimicrobial stewardship has been a key area informed by NRN findings.

Conclusions:

  • NRN research is vital for informing evidence-based practices in neonatal care.
  • The network's contributions have improved the management and outcomes of neonatal infections.
  • Continued research is essential for addressing evolving challenges in neonatal infectious diseases.