Related Experiment Video
Updated: Sep 4, 2025
06:39
Three-dimensional Location Approach with Silk Thread Guided Laparoscopic Segmentectomy for Liver Tumor
Published on: May 23, 2025
129
Radiologic-pathologic correlation of lesions in resected liver specimens with an ex vivo MRI-compatible localization
Victoria R Rendell1, Emily R Winslow1,2, Timothy J Colgan3
1Department of Surgery, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA.
European Radiology
|July 21, 2022
Summary
This study shows an MRI-compatible device can accurately locate small liver lesions in resected specimens. This radiologic-pathologic correlation aids in precise histological characterization for better liver disease diagnosis.
Area of Science:
- Medical Imaging
- Pathology
- Surgical Oncology
Background:
- Accurate liver lesion characterization is challenged by the absence of a gold standard for correlating imaging findings with histology.
- Precise radiologic-pathologic correlation is crucial for understanding liver lesion behavior and guiding treatment.
Purpose of the Study:
- To assess the feasibility of an ex vivo MRI-compatible sectioning device for radiologic-pathologic co-localization of liver lesions.
- To enable precise histological characterization of resected liver specimens using advanced imaging techniques.
Main Methods:
- A prospective feasibility study involving adult patients undergoing partial hepatectomy.
- Utilized an MRI-compatible device with a 3D matrix for stabilizing liver specimens.
- Acquired high-resolution 3D T1- and T2-weighted MRI sequences for lesion identification and localization.
Main Results:
- Successfully co-localized 91% (52/57) of radiologically identified liver lesions.
- The device accurately identified small lesions (< 1 cm), with 67% of lesions being smaller than 1 cm.
- MRI-guided localization confirmed 10% of lesions not initially apparent on gross examination.
Conclusions:
- The ex vivo MRI-compatible sectioning device offers a feasible and reliable method for radiologic-pathologic correlation of liver lesions.
- This technique is suitable for clinical practice and future research in liver lesion characterization.
- Intraoperative gadoxetic acid administration enhances ex vivo MRI image quality for improved lesion detection.
