Related Experiment Video
Updated: Sep 4, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
526
CircLONP2 Accelerates Esophageal Squamous Cell Carcinoma Progression via Direct MiR-27b-3p-ZEB1 Axis
Cailin Zhu1, Weiyun Bi2, Hongtao Li3
1Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in Oncology
|July 22, 2022
Summary
Circular RNAs (circRNAs) are upregulated in esophageal squamous cell carcinoma (ESCC), promoting cancer progression. CircLONP2 acts as an oncogenic factor, potentially serving as a prognostic biomarker for ESCC patients.
Area of Science:
- Molecular Biology
- Oncology
- Cancer Research
Background:
- Circular RNAs (circRNAs) play a significant role in the development of esophageal squamous cell carcinoma (ESCC).
- Understanding the specific functions of circRNAs, such as circLONP2, is crucial for deciphering ESCC carcinogenesis.
Purpose of the Study:
- To investigate the functional roles and underlying mechanisms of circLONP2 in the progression of ESCC.
- To evaluate circLONP2 as a potential prognostic biomarker for ESCC.
Main Methods:
- Quantification of circLONP2 levels in ESCC patient samples and cell lines.
- In vitro experiments to assess the impact of circLONP2 on ESCC cell proliferation and migration.
- Mechanistic studies involving interactions with microRNAs (miRNAs) and target gene expression analysis (miR-27b-3p, ZEB1).
Main Results:
- CircLONP2 expression is significantly upregulated in human ESCC tissues and cell lines.
- Elevated circLONP2 levels correlate with poorer overall survival (OS) and disease-free survival (DFS) in ESCC patients.
- CircLONP2 promotes ESCC aggressiveness by sponging miR-27b-3p, leading to increased ZEB1 expression and epithelial-to-mesenchymal transition (EMT).
Conclusions:
- The circLONP2/miR-27b-3p/ZEB1 axis drives ESCC metastasis through regulation of EMT.
- CircLONP2 functions as an oncogenic circRNA in ESCC.
- CircLONP2 holds promise as a valuable prognostic biomarker for predicting patient outcomes in ESCC.
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