Related Experiment Video
Updated: Sep 4, 2025
06:49
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
Published on: November 20, 2016
9.0K
Keratopathy in Noonan Syndrome
Yelin Yang1, Jyh Haur Woo1,2, Asim Ali1,3
1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.
Cornea
|July 22, 2022
Summary
Noonan syndrome can cause serious vision problems due to corneal scarring and vascularization. Early detection and treatment of this keratopathy are crucial to prevent vision loss.
Area of Science:
- Ophthalmology
- Genetics
- Corneal Diseases
Background:
- Noonan syndrome is a rare genetic disorder.
- Anterior segment abnormalities, particularly keratopathy, are uncommon manifestations.
Observation:
- Two young male patients with Noonan syndrome presented with progressive corneal abnormalities.
- Both patients developed recurrent corneal scarring, vascularization, and vision deterioration despite initial treatments.
Findings:
- The patients exhibited inferior epitheliopathy, corneal scarring, and vascularization, leading to significant vision loss.
- Histopathology revealed a disturbed Bowman layer and fibrous tissue, suggesting an abnormal fibrotic response.
Implications:
- Noonan syndrome should be considered in the differential diagnosis of visually significant keratopathy.
- Prompt diagnosis and management of keratopathy in Noonan syndrome patients are essential to preserve vision and avoid surgery.
More Related Videos
Related Concept Videos
01:22Photoreceptors and Visual Pathways
6.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.4K
01:25Glaucoma: Overview
712
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
712
01:28Angle Closure Glaucoma: Treatment
639
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
639
00:50Unrenewable Cells
2.3K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.3K