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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Cyclodextrin-based delivery systems in parenteral formulations: A critical update review
Laura Ferreira1, Joana Campos2, Francisco Veiga1
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal.
Summary
Cyclodextrins (CDs) enhance parenteral drug formulations by improving solubility and stability. These versatile excipients are key to developing advanced injectable drug delivery systems for chronic diseases and emergency care.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Supramolecular Chemistry
Background:
- Parenteral formulations are critical for drugs unsuitable for oral administration, like proteins and anticancer agents.
- Developing parenteral drugs is complex due to stringent safety and quality requirements.
- Cyclodextrins (CDs) offer a strategy to overcome challenges in parenteral formulation development.
Purpose of the Study:
- To highlight the advantages of using cyclodextrins (CDs) in parenteral formulations.
- To discuss the role of CDs in improving drug properties for injection.
- To explore the application of CDs in advanced injectable systems.
Main Methods:
- Formation of water-soluble host-guest inclusion complexes with cyclodextrins.
- Utilizing CDs as building blocks for nanoparticles and supramolecular hydrogels.
- Reviewing the safety and regulatory acceptance of parenteral cyclodextrins.
Main Results:
- CDs improve the apparent water-solubility, chemical stability, and bioavailability of drugs.
- CD-based nanoparticles and hydrogels show promise for anticancer drug delivery.
- Approved parenteral CDs facilitate the development of safer, more effective injectable formulations.
Conclusions:
- Cyclodextrins are valuable pharmaceutical excipients for parenteral drug development.
- CDs enable the creation of advanced injectable drug delivery systems.
- Regulatory acceptance of CDs promotes innovation in parenteral formulations.
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