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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

50
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

69
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
69

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Updated: Sep 3, 2025

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Pediatric Liver Transplantation.

Sara Kathryn Smith1, Tamir Miloh2

  • 1Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA.

Clinics in Liver Disease
|July 22, 2022
PubMed
Summary
This summary is machine-generated.

Pediatric liver transplantation (LT) offers excellent survival rates and significantly improves quality of life for children with severe liver conditions. This review covers key aspects of pediatric LT, from evaluation to post-transplant care.

Keywords:
End stage liver diseaseImmunosuppressionLiver failureLiver rejectionLiving donor transplantPediatric liver transplantSplit liver transplant

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Area of Science:

  • Hepatology
  • Pediatric Surgery
  • Transplant Immunology

Background:

  • Liver transplantation (LT) is a critical intervention for pediatric patients suffering from acute or chronic liver disease, hepatic tumors, and certain genetic metabolic disorders.
  • Successful LT in children leads to excellent short- and long-term patient and graft survival, offering a life-saving option.
  • This procedure can dramatically enhance the quality of life for affected children.

Purpose of the Study:

  • To provide a comprehensive overview of pediatric liver transplantation.
  • To discuss the unique considerations and challenges associated with LT in pediatric populations.
  • To cover all stages of the pediatric LT journey, from initial evaluation to long-term management.

Main Methods:

  • Review of current literature and clinical practices in pediatric liver transplantation.
  • Discussion of established protocols for patient selection, organ allocation, and surgical techniques.
  • Analysis of post-transplant care strategies, including immunosuppression and long-term follow-up.

Main Results:

  • Pediatric LT demonstrates high rates of patient and graft survival.
  • The procedure is effective in treating a range of pediatric liver conditions, improving long-term outcomes.
  • Careful patient selection, surgical expertise, and meticulous post-transplant management are crucial for success.

Conclusions:

  • Pediatric liver transplantation is a highly successful and life-altering treatment for children with end-stage liver disease.
  • The article highlights the multidisciplinary approach required for optimal pediatric LT outcomes.
  • Key areas discussed include indications, surgical nuances, immunosuppression, and the transition of care to adult services.