[Method of determining separate kidney clearance]

The task was to develop a simple and effective method of radionuclide determination of separate clearance of the kidneys (SCK), i.e. separate assessment of secretory-excretory function of each kidney. The other earlier known methods of SCK determination were either methodologically incorrect or very difficult. A method of SCK determination intended both for gamma-chambers and standard radiographic units based on common renographic methods, was proposed. An algorithm for processing of measurement results was based on the generalization of the mathematical apparatus of circulation models usually employed for a study of the central and organ hemodynamics, and on its development for transitory nephrotropic radiopharmaceuticals (RP). An investigation of 21 healthy persons and 51 patients with renal tumors using 131I-hippuran showed that the proposed method possessed sufficient sensitivity for its clinical use. Advantages and shortcomings of the method were analysed. All the allowances were justifiable.