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Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study
Andrés Fernando Vinueza Veloz1, Tannia Valeria Carpio Arias2, Jénifer Sthefania Vargas Mejía3
1Department of Neurology, Hermanos Ameijeiras Hospital, La Habana, Cuba.
Clinical Nutrition ESPEN
|July 25, 2022
Summary
Low vitamin B12 levels are linked to cognitive decline in older adults, particularly those over 75. Vitamin D levels showed no association with cognitive function in this study.
Area of Science:
- Gerontology
- Nutritional Neuroscience
- Epidemiology
Background:
- Sub-clinical deficiencies in vitamin B12 and D are poorly understood in relation to cognitive decline.
- Assessing these nutrient levels is crucial for understanding cognitive aging.
Purpose of the Study:
- To investigate the association between vitamin B12 and D levels and cognitive function in community-dwelling elders.
- To identify potential nutritional risk factors for cognitive impairment in aging populations.
Main Methods:
- A cross-sectional study utilizing data from the population-based SABE study in Ecuador.
- Blood samples were analyzed for vitamin B12 and D levels.
- Cognitive status was evaluated using an abbreviated version of the Mini-Mental State Examination (MMSE).
Main Results:
- Vitamin B12 levels were significantly associated with MMSE scores, independent of various demographic factors.
- The association between vitamin B12 and cognitive function was age-dependent, with a steeper decline observed in individuals over 75 years old with low vitamin B12.
- No significant association was found between vitamin D levels and cognitive function.
Conclusions:
- Low vitamin B12 levels are associated with reduced cognitive functioning in community-dwelling elders.
- Vitamin D deficiency does not appear to be linked to cognitive function in this population.
- Targeting vitamin B12 levels may be a strategy to support cognitive health in older adults.
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