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COVID-19 with Extreme Thrombocytosis: A Case Report and Its Possible Mechanisms

Cathleen Kenya1, Nur Chandra Bunawan2, Hardijatmo Muljo Nugroho2

  • 1Regional Public Hospital of Kramat Jati, Jakarta, Indonesia.

Caspian Journal of Internal Medicine
|July 25, 2022
PubMed

Insights

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) can cause extreme thrombocytosis in COVID-19 patients. Monitoring platelet counts is crucial for anticipating disease progression.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Virology

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic with diverse clinical presentations.
  • Hematologic manifestations are common in COVID-19, with thrombocytopenia being more frequent than thrombocytosis.
  • Understanding the spectrum of COVID-19 hematologic findings is critical for patient management.

Observation:

  • A case of a 55-year-old woman with COVID-19 is presented, initially diagnosed with mild symptoms.
  • The patient developed progressive thrombocytosis, with platelet counts exceeding 1000 x10^9/L.
  • This extreme thrombocytosis occurred alongside a worsening clinical condition.

Findings:

  • COVID-19 can manifest with severe thrombocytosis, a rare but significant hematologic finding.
  • The presented case highlights an unusual association between SARS-CoV-2 infection and extremely elevated platelet counts.
  • The study aims to explore potential mechanisms underlying this phenomenon.

Implications:

  • Extreme thrombocytosis in COVID-19 patients may indicate a worsening clinical state.
  • Regular monitoring of platelet counts in hospitalized COVID-19 patients is recommended.
  • This monitoring can aid in the early identification of severe disease progression and inform treatment strategies.
Abstract

Keywords:
COVID-19SARS-CoV-2hematologic manifestationsplatelet countthrombocytosis

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