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Direct Relationship Between Uric Acid and C-Reactive Protein and Its Implication in the Chronic Kidney Disease

Jaya Jeena1, Sunita Manhas1, Rajendra Prasad1

  • 1Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana India.

Indian Journal of Clinical Biochemistry : IJCB
|July 25, 2022
PubMed

Insights

Serum uric acid and C-Reactive protein (CRP) are elevated in chronic kidney disease (CKD) patients. These biomarkers show a strong direct relationship, suggesting they contribute to CKD progression.

Area of Science:

  • Nephrology
  • Clinical Biochemistry

Background:

  • Chronic Kidney Disease (CKD) presents a significant health burden in India, contributing to high morbidity and mortality.
  • A potential link between serum uric acid and C-Reactive protein (CRP) is implicated in CKD's pathological processes.

Purpose of the Study:

  • To investigate the relationship between serum uric acid and CRP levels in CKD patients.
  • To compare these levels between CKD patients and healthy controls.

Main Methods:

  • Serum uric acid and C-Reactive protein (CRP) were measured in 50 CKD patients (pre-dialysis) and 50 controls.
  • Quantitative turbidimetric immunoassay was used for CRP measurement.
  • Standard biochemical analyses were performed.

Main Results:

  • CKD patients exhibited significantly higher levels of serum uric acid, creatinine, urea, and CRP compared to controls.
  • CRP levels were notably higher in non-diabetic CKD patients than in diabetic CKD patients.
  • A Receiver Operating Characteristic (ROC) curve analysis revealed a strong association between uric acid and CRP.

Conclusions:

  • A significant direct correlation exists between serum uric acid and CRP in CKD patients.
  • Elevated levels of both uric acid and CRP are strongly associated with CKD progression.

Keywords:
C-reactive proteinChronic kidney diseaseCreatinineHypertensionType 2 diabetesUric acid

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