Related Experiment Video
Updated: Sep 3, 2025
05:44
Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
Published on: January 12, 2017
10.1K
Correlation Analysis of Ultrasound Elastography Score with Invasive Breast Cancer and Biological Prognostic Factors
1Department of Ultrasound, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi 214002, Jiangsu, China.
Contrast Media & Molecular Imaging
|July 25, 2022
Summary
Ultrasound elastography score (UES) can diagnose invasive breast cancer (IBC) with high accuracy. UES also correlates with key prognostic factors like progesterone receptor, HER2, and Ki67, aiding in patient prognosis.
Area of Science:
- Oncology
- Medical Imaging
- Pathology
Background:
- Invasive breast cancer (IBC) is a malignant tumor where cancer cells invade surrounding tissue.
- Ultrasound elastography score (UES) shows promise in IBC diagnosis, but its prognostic value is unclear.
Purpose of the Study:
- To explore the correlation between UES and IBC.
- To investigate the relationship of UES with biological prognostic factors.
Main Methods:
- Collected data from 86 patients with suspected IBC.
- Utilized ultrasound elastography (UE) for examination.
- Analyzed expression of Estrogen Receptor (E receptor), Progesterone Receptor (P receptor), HER2, and Ki67.
- Employed Receiver Operating Characteristic (ROC) curve analysis, multiple linear regression, and Spearman correlation.
Main Results:
- UES demonstrated significant diagnostic value for IBC (AUC=0.877, sensitivity=92.42%, specificity=90.00%).
- UES showed significant correlation with P receptor, HER2, and Ki67 expression (P<0.05).
- No significant variance in UES was observed for E receptor expression (P>0.05).
Conclusions:
- UES is a valuable tool for diagnosing IBC.
- UES correlates with key prognostic factors (P receptor, HER2, Ki67), assisting in evaluating IBC patient prognosis.
