Transformation of zinc oxide nanoparticles in synthetic lung fluids

Surface coatings, including paints, stains, and sealants, have recently become a focus of "nano-enabled" consumer product engineering. Specifically, zinc oxide (ZnO) nanoparticles (NPs) have been introduced to surface coatings to increase UV resistance. As more "nano-enabled" products are made available for purchase, questions arise regarding their long-term environmental and human health effects. This study tracked the transformation of NP additives commonly added to consumer paints and stains using ZnO NPs as a model system. During product application and use, there is a risk of inhalation of aerosolized ZnO NPs. To investigate the potential chemical interactions and transformations that would occur after inhalation, ZnO NPs were incubated in two synthetic lung fluids (SLFs). Initial studies utilized ZnO NPs dispersed in Milli-Q water (control), or a commercially available deck stain. Additionally, two commercially available products advertising the inclusion of ZnO NP additives were evaluated. Subsamples were taken throughout incubation and analyzed via atomic absorption spectroscopy to determine both the total (including particulate) zinc concentration and dissolved (non-particulate) zinc concentration. Results indicate that the vast majority of ZnO transformation takes place within the first 24 h of incubation and is primarily driven by SLF pH and composition complexity. Significant dissolution of ZnO NPs was observed when incubated in Gamble's solution (between 25 and 68% depending on the matrix. Additionally, all ZnO solutions saw near immediate dissolution (~ 98-100%) within 3 h of incubation in artificial lysosomal fluid. Results illustrate potential for NPs in consumer products to undergo significant transformation during use and exposure over short time periods.

The online version contains supplementary material available at 10.1007/s11051-022-05527-y.