Recent progress and perspectives of continuous in vivo testing device

Area of Science:

• Biomedical Engineering
• Medical Diagnostics
• Nanomaterials Science

Background:

• Continuous in-vivo testing (CIVT) devices provide real-time physiological and metabolic data, crucial for monitoring patient conditions and therapeutic responses.
• Current CIVT technology is limited to detecting only a few key markers, hindering comprehensive patient assessment and disease pathogenesis research.
• The demand for advanced CIVT is driven by its potential to significantly improve disease diagnosis, treatment efficacy, and understanding of human pathogenesis.

Purpose of the Study:

• To comprehensively review recent advancements in CIVT device development.
• To analyze the structural components, detection principles, and nanomaterials used in CIVT devices.
• To identify the limitations of current CIVT technology and outline future research directions for detecting a wider range of markers.

Main Methods:

• Literature review of recent progress in CIVT device development.
• Analysis of device structures, continuous detection principles, and nanomaterial applications for electrode modification.
• Evaluation of the advantages and disadvantages of existing CIVT devices.

Main Results:

• CIVT devices offer real-time monitoring capabilities for various physiological parameters.
• Challenges remain in expanding CIVT to detect a broader spectrum of clinically significant markers.
• Nanomaterials play a critical role in enhancing the sensitivity and specificity of CIVT sensors.

Conclusions:

• Further development of CIVT is essential for personalized medical treatments and enhanced disease management.
• Overcoming current technological hurdles is necessary to expand the application of CIVT to more biomarkers.
• This review provides a foundational reference for researchers and developers in the field of CIVT.