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Some miRNA expressions and their targets in ischemic stroke
Ummugulsum Can1, Ebru Marzioglu2, Sadinaz Akdu3
1Department of Biochemistry, Konya City Hospital, Konya, Türkiye.
Nucleosides, Nucleotides & Nucleic Acids
|July 25, 2022
Summary
MicroRNAs (miRNAs) show promise as diagnostic biomarkers for ischemic stroke (IS). This review summarizes studies on miRNA expression and targets, highlighting their potential for rapid IS diagnosis.
Area of Science:
- Biochemistry
- Genetics
- Neurology
Background:
- Ischemic stroke (IS) is a major cause of disability and death globally.
- IS results from complex interactions between genetic and environmental factors.
- Early diagnosis of acute IS is crucial for effective treatment.
Purpose of the Study:
- To investigate microRNA (miRNA) expressions and their targets in ischemic stroke.
- To evaluate the potential of miRNAs as biomarkers for rapid IS diagnosis.
Main Methods:
- Systematic review of existing studies on miRNA expression in IS.
- Analysis of miRNA targets implicated in IS pathophysiology.
Main Results:
- miRNAs are stable and easily detectable in blood, making them suitable biomarkers.
- Specific miRNA expressions are associated with IS.
- miRNA targets play a role in IS development.
Conclusions:
- miRNAs hold significant potential as diagnostic biomarkers for ischemic stroke.
- Further research into miRNA expression patterns can lead to improved diagnostic tools for IS.
- Understanding miRNA targets can offer insights into IS mechanisms.
