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Cardiac Remodelling Following Cancer Therapy: A Review

Tan Panpan1, Du Yuchen2, Shi Xianyong3

  • 1Puyang Medical College, Henan, 457000, China. pyyz_tpp@126.com.

Cardiovascular Toxicology
|July 25, 2022
PubMed

Insights

Cancer therapies like chemotherapy and immunotherapy can cause cardiac remodelling, leading to heart damage. This review explains the mechanisms behind these heart changes induced by anti-cancer treatments.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Cardiac remodelling involves detrimental changes in heart structure and function.
  • These changes include alterations in size, shape, fibrosis, and inflammation, potentially leading to heart failure.

Purpose of the Study:

  • To elucidate the fundamental mechanisms of cardiac remodelling induced by various cancer therapies.
  • To provide a comprehensive overview of how anti-cancer treatments affect heart health.

Main Methods:

  • This is a review article, synthesizing existing research on cancer therapy-induced cardiotoxicity.
  • The review examines mechanisms of cardiac damage from radiation and specific drug classes.

Main Results:

  • Radiation and anti-cancer drugs (chemotherapy, RTKIs, ICIs) can induce cardiac remodelling.
  • Mechanisms include inflammation, fibrosis, and vascular remodelling, impacting heart function.

Conclusions:

  • Understanding these mechanisms is crucial for managing cardiotoxicity in cancer patients.
  • Further research can inform strategies to mitigate heart damage during cancer treatment.

Keywords:
Cardiac remodellingChemotherapyFibrosisRadiationValvular heart diseases

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