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Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer

Mehrnoosh Pauls1, Stephen Chia1, Nathalie LeVasseur1

  • 1BC Cancer Vancouver Centre, University of British Columbia, 600 W 10th Ave, Vancouver, BC V5Z 4E6, Canada.

Current Oncology (Toronto, Ont.)
|July 25, 2022
PubMed

Insights

Triple-negative breast cancer (TNBC) is hard to treat due to its diversity. This review covers current therapies like immunotherapy and new treatments for advanced TNBC.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Triple-negative breast cancer (TNBC) presents a significant clinical challenge.
  • Its heterogeneity and lack of specific targets contribute to a poorer prognosis.

Purpose of the Study:

  • To review current standard-of-care treatments for metastatic TNBC.
  • To explore emerging therapies and novel combinations for advanced TNBC.

Main Methods:

  • Literature review of existing and novel treatment modalities.
  • Discussion of recent advancements in TNBC therapeutics.

Main Results:

  • Current treatments include immunotherapy, PARP inhibitors, and antibody-drug conjugates.
  • New agents and combination therapies are under investigation.

Conclusions:

  • Despite challenges, advancements in immunotherapy and targeted therapies offer new hope for TNBC patients.
  • Further research into novel agents and combinations is crucial for improving outcomes in advanced TNBC.
Keywords:
PARP inhibitorPI3K/AKT/mTORantibody-drug conjugate (ADC)immunotherapymetastatic TNBC

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