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Lotus Seedpod-Inspired Crosslinking-Assembled Hydrogels Based on Gold Nanoclusters for Synergistic Osteosarcoma
Zhe Yang1, Zuhao Li2, Yue Zhao1
1State Key Laboratory of Supramolecular Structure and Material, College of Chemistry, Jilin University, Changchun 130012, China.
ACS Applied Materials & Interfaces
|July 25, 2022
Summary
Injectable hydrogels inspired by lotus seedpods offer a novel synergistic treatment for osteosarcoma. This approach combines advanced imaging and photothermal therapy for effective tumor ablation with reduced systemic toxicity.
Area of Science:
- Biomaterials Science
- Oncology
- Nanotechnology
Background:
- Osteosarcoma resection is challenging due to bone matrix damage.
- Current treatments like chemotherapy and radiotherapy cause systemic injury.
- Developing bone-specific treatments remains a significant challenge.
Purpose of the Study:
- To develop injectable hydrogels for synergistic osteosarcoma treatment.
- To create a system with long-term retention and imaging capabilities.
- To improve upon existing osteosarcoma therapeutic strategies.
Main Methods:
- Synthesized injectable hydrogels (HG-CAHs) using oxidized hyaluronic acid (HA-ALD) and gold nanoclusters (GNCs).
- Utilized dynamic amide bonds for in situ crosslinking assembly.
- Incorporated doxorubicin (Dox) for localized, responsive drug release.
Main Results:
- HG-CAHs demonstrated enhanced photothermal therapy (PTT) ability and high biocompatibility.
- Maintained the fluorescence (FL) and computed tomography (CT) imaging functions of GNCs for persistent osteosarcoma visualization.
- Exhibited excellent mechanical properties and pH/NIR-responsive Dox release, efficiently ablating osteosarcoma with reduced toxicity.
Conclusions:
- The lotus seedpod-inspired hydrogels provide a promising new platform for osteosarcoma treatment.
- This synergistic approach integrates imaging, PTT, and chemotherapy effectively.
- The developed system offers a potential next-generation therapeutic strategy for osteosarcoma.
