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Updated: Sep 3, 2025

Angiogenesis in the Ischemic Rat Lung
Published on: February 8, 2013
[The bronchial arteries: a small but vital contribution to lung perfusion after lung transplantation]
Ulrich Koehler1, Olaf Hildebrandt1, Regina Conradt1
1Pneumologie, Philipps-Universität Marburg, Marburg, Germany.
Abstract:
Blood supply to the lungs is carried out by the pulmonary and bronchial-arterial system. The bronchial-arterial vessels are involved in supplying the small airways all the way up to the terminal bronchioles. The bronchial-arterial system is also necessary for the regulation of airway temperature, humidity and mucociliary clearance. Chronic ischaemia of the small airways due to damage or injury to bronchial arterial supply increases the risk of fibrosis of the small airways (bronchiolitis obliteration), especially in lung transplantation (LTx). Although survival after LTx has improved over time, it is, with a 5-year survival rate of only 50 to 60%, still significantly worse than that of other organ transplants. It is likely that bronchial arterial revascularisation at the time of LTx plays an important transplant-preserving function.
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