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What Is Normal for an Aging Heart?: A Prospective CMR Cohort Study
Johannes Kersten1, Carsten Hackenbroch2, Muriel Bouly3
1University of Ulm, Internal Medicine II, Ulm, Germany. johannes.kersten@uni-ulm.de.
Journal of Cardiovascular Imaging
|July 25, 2022
Summary
Aging hearts show reduced ventricular volumes but normal ejection fractions. Myocardial T1 values and aortic distensibility decrease, indicating age-related remodeling. Type 2 diabetes has minimal impact on these cardiac aging changes.
Area of Science:
- Cardiovascular Imaging
- Cardiology
- Radiology
Background:
- Investigates normal age-related changes in the heart using cardiac magnetic resonance (CMR) imaging.
- Examines the influence of type 2 diabetes mellitus on cardiac aging in healthy individuals.
Purpose of the Study:
- To characterize normal aging of the heart in healthy volunteers via CMR.
- To assess the impact of type 2 diabetes on these aging processes.
Main Methods:
- Prospective single-center trial involving 75 healthy subjects across age groups and 10 healthy diabetics.
- Utilized a 1.5T CMR scanner for functional, flow-sensitive, T2-mapping, and T1-mapping sequences.
Main Results:
- Significant decrease in bi-ventricular volumes (p<0.001) with age.
- Reduced myocardial T1 values, aortic distensibility, and left ventricular peak diastolic strain rates observed with aging.
- No significant differences in ejection fractions, T2 mapping, or deformation parameters between aging groups; type 2 diabetes showed minimal impact.
Conclusions:
- Healthy heart aging is characterized by decreased ventricular volumes and preserved ejection fractions.
- Myocardial and aortic stiffening, along with decreased T1 values, suggest age-related cardiac remodeling.
- Type 2 diabetes mellitus does not appear to significantly influence the observed cardiac aging processes.
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