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Updated: Sep 3, 2025
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Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
Published on: May 5, 2022
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Immune senescence in multiple myeloma-a role for mitochondrial dysfunction?
Frances Seymour1, Jonathan Carmichael2,3, Claire Taylor4
1Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK. frances.seymour1@nhs.net.
Leukemia
|July 25, 2022
Summary
Immunosenescence, or immune system aging, accelerates aging and frailty, particularly in multiple myeloma (MM). Understanding immunometabolic dysfunction is key to overcoming MM treatment barriers.
Area of Science:
- Immunology
- Gerontology
- Oncology
Background:
- Age-related immune dysfunction (immunosenescence) leads to poor pathogen clearance, reduced vaccine efficacy, and increased comorbidities.
- Immunometabolic abnormalities and inflammaging contribute to accelerated aging and frailty syndromes.
- Cancer, such as multiple myeloma (MM), can accelerate immunosenescence in a bidirectional relationship with inflammaging.
Purpose of the Study:
- To outline the understanding of normal immune aging.
- To describe mechanisms of immunometabolic dysfunction in accelerating immune aging.
- To propose the role of these processes in the pathogenesis of multiple myeloma.
Main Methods:
- Review of current understanding of immune aging.
- Description of immunometabolic dysfunction mechanisms.
- Proposal of the role of these processes in MM pathogenesis.
Main Results:
- Immunosenescence is a primary driver of age-related immune dysfunction.
- Immunometabolic dysfunction and inflammaging accelerate aging and frailty.
- MM exemplifies the interplay between host response biology and disease-induced immune dysfunction.
Conclusions:
- Understanding accelerated immune aging and MM's influence is crucial for overcoming therapeutic challenges.
- Cellular mitochondrial dysfunction is linked to abnormal immune phenotypes with broad physiological consequences.
- Further research into immunometabolic dysfunction in MM pathogenesis is warranted.
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