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Primary amoebic meningoencephalitis in children- report of two cases from South India
Ranjit Baby Joseph1, Abdul Rauf2, Akbar Mohamed Chettali1
1Department of Pediatrics, 416649Aster Medcity, Kochi, Kerala, India.
Abstract:
Primary Amoebic meningoencephalitis is a rare and fatal neuro-infection caused by free-living fresh-water amoeba Naegleria fowleri. It is a ubiquitous organism and the infection occurs usually via contact with warm water-bodies. The clinical presentation is often indistinguishable from acute bacterial meningitis and the diagnosis can be made by CSF wet smear examination if there is a high index of suspicion. The disease progresses rapidly compared to pyogenic meningitis and usually has a fatal outcome. Reports of two confirmed cases of primary amoebic meningoencephalitis in children from different centres in Kerala state of India are presented here. In spite of early diagnosis and treatment, both these patients demised. Primary amoebic meningoencephalitis should be considered in the differential diagnosis of acute meningitis, especially in patients with recent freshwater exposure. Implementation of chlorination of pools of water bodies, especially if re-opened for recreational purpose after prolonged periods of non-use, needs vigorous implementation.
Insights
Primary Amoebic Meningoencephalitis (PAM) is a rare, fatal brain infection caused by Naegleria fowleri. Early diagnosis and treatment were unsuccessful in two pediatric cases in India, highlighting the need for awareness.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Primary Amoebic Meningoencephalitis (PAM) is a rare and fatal neuro-infection.
- It is caused by the free-living amoeba Naegleria fowleri, commonly found in warm freshwater bodies.
- Infection typically occurs through nasal passages during water activities.
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