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Aquagenic keratoderma.

Eduardo Marín-Hernández¹, María J García-Alonso², Erick D Cruz-Flores¹

¹Servicio de Dermatología Pediátrica, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social.

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|July 26, 2022

Summary

Aquagenic keratoderma causes wrinkling and papules on palms after water contact. This underdiagnosed condition may indicate underlying systemic diseases like cystic fibrosis.

Keywords:

Acroqueratodermia acuagénica siríngea Aquagenic acrokeratoderma syringeal Aquagenic keratoderma Queratodermia acuagénica Siringe Syrinx

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Area of Science:

Dermatology
Medical Case Reports

Background:

Aquagenic keratoderma is a skin condition triggered by water exposure, presenting as papules and macerated plaques on palms and soles.
It can be idiopathic or associated with conditions like cystic fibrosis, atopy, malnutrition, or certain medications.

Observation:

A 17-year-old female with chronic abdominal pain presented with palmar "wrinkling" after water contact.
Clinical examination revealed hyperlinearity, translucent papules, and macerated plaques. Dermoscopy showed whitish, anfractive structures resembling coral.
Histopathology confirmed hyperkeratosis and acrosyringium dilation.

Findings:

The patient was diagnosed with aquagenic keratoderma based on clinical and histological findings.
Treatment initiated resulted in partial symptom improvement.

Implications:

Aquagenic keratoderma is often underdiagnosed and can serve as a marker for systemic diseases, notably cystic fibrosis.
The authors propose a descriptive nomenclature: "whitish macerated aquagenic plaques of the acrosyringium".
Further case reporting is crucial for better understanding, management, and patient follow-up.