Coronary anomalies associated with ventricular septal defect
Masaru Kobayashi1, Jun Muneuchi2, Yuichiro Sugitani1
1Department of Pediatrics, Kyushu Hospital, Japan Community Healthcare Organization, 1-8-2, Kishionura, Yahatanishi-ku, Kitakyushu, Fukuoka, 806-8507, Japan.
Heart and Vessels
|July 26, 2022
Summary
Coronary anomalies occurred in 6.2% of patients with ventricular septal defect. These anomalies were linked to bicuspid aortic valve and persistent left superior caval vein, suggesting minor cardiac variants increase risk.
Area of Science:
- Cardiology
- Congenital Heart Disease
- Medical Imaging
Background:
- Coronary anomalies present diverse origins, coursing, and branching patterns.
- They are sometimes linked to congenital heart disease.
- Ventricular septal defect is a common congenital heart disease.
Purpose of the Study:
- To investigate coronary anomalies in patients with ventricular septal defect.
- To determine the prevalence and types of coronary anomalies in this population.
- To identify factors associated with coronary anomalies in ventricular septal defect patients.
Main Methods:
- Retrospective review of angiographic findings in 998 patients with ventricular septal defect.
- Identification of coronary abnormalities based on angiography.
- Statistical analysis to determine correlations with other cardiac conditions.
Main Results:
- The overall prevalence of coronary anomalies was 6.2%.
- Anomalous origin and coursing were the primary types observed.
- Coronary anomalies were independently correlated with bicuspid aortic valve (OR: 8.02) and persistent left superior caval vein (OR: 5.02).
Conclusions:
- Minor cardiac variants like bicuspid aortic valve and persistent left superior caval vein may increase the prevalence of coronary anomalies in ventricular septal defect patients.
- Angiography is crucial for identifying coronary anomalies in this cohort.
- Further research into the embryological links between these conditions is warranted.
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