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Moisture-resistant and green cyclodextrin metal-organic framework nanozyme based on cross-linkage for visible
Bing Tan1, Shasha Zhang2, Kemeng Wang2
1Key Laboratory for Yellow River and Huai River Water Environmental Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Engineering Laboratory of Environmental Functional Materials and Pollution Control, International Joint Laboratory On Key Techniques in Water Treatment, Henan Province, School of Environment, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China. tanbing@htu.edu.cn.
Abstract:
A moisture-resistant and green cyclodextrin metal-organic framework (CD-MOF) nanosheet has been prepared via an one-pot antisolvent synthesis procedure. After the treatment of in situ chemical cross-linkage, the two-dimensional (2D) cross-linked CD-MOF exhibited both peroxidase (POD) and oxidase (OXD) enzymatic activities, as well as hydrolytic stability. On the basis of its POD mimics function, the proof-of-concept biosensors were constructed to realize the colorimetric detection for H2O2 and glucose, respectively. In vitro cytotoxicity experiments showed that the 2D cross-linked CD-MOF nanozymes still maintained excellent biocompatibility even at a concentration reaching up to several mg/mL. The in situ colorimetric detection of H2O2 secreted by HepG2 cells further confirmed its promising biocompatibility, showing its great promises as label-free colorimetric probe in early cancer detection and pathological process monitoring.
