Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

315
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
315
Physiological Control of Respiration01:23

Physiological Control of Respiration

2.9K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.9K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

3.1K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
3.1K
Special considerations while measuring oxygen saturation01:19

Special considerations while measuring oxygen saturation

695
Assessing respiratory rate concurrently with pulse measurement is fundamental to patient care, providing valuable insights into the patient's respiratory function. The normal breathing rate for an adult usually falls within a normal range of 12 to 20 breaths per minute. Abnormal respiratory rates can signal underlying health conditions or the need for immediate intervention.
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
695
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.1K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.1K
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

33
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
33

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Impact of Embolization on Outcomes in Iliopsoas Hematomas: A Multicenter Retrospective Propensity-matched Study.

Academic radiology·2026
Same author

Outcome After Surgery for Type A Intramural Hematoma.

Journal of cardiovascular development and disease·2026
Same author

DECT-based stratification of nonocclusive mesenteric ischemia using bowel-wall iodine concentration: a prospective single-center cohort.

European radiology experimental·2026
Same author

Sudden hemodynamic collapse and biventricular dysfunction: What's your diagnosis?

Intensive care medicine·2026
Same author

Novel treatment strategies in cardiogenic shock: an update on ongoing clinical trials.

Heart failure reviews·2026
Same author

Postcardiotomy veno-arterial membrane oxygenation as a bridge to heart replacement therapies.

Heart & lung : the journal of critical care·2026

Related Experiment Video

Updated: Sep 3, 2025

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

425

Optimizing PO2 during peripheral veno-arterial ECMO: a narrative review.

Hadrien Winiszewski1,2, Pierre-Grégoire Guinot3, Matthieu Schmidt4

  • 1Service de Réanimation Médicale, centre hospitalier universitaire de Besançon, Besançon, France. hwiniszewski@chu-besancon.fr.

Critical Care (London, England)
|July 26, 2022
PubMed
Summary

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can cause hyperoxemia. Targeting postoxygenator oxygen (PPOSTO2) around 150 mmHg aims to balance avoiding hypoxemia and severe hyperoxemia during VA-ECMO support.

Keywords:
Dual circulationHyperoxemiaMixing zoneOxygenVeno-arterial ECMO

More Related Videos

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
06:41

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

12.6K
Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
09:47

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

685

Related Experiment Videos

Last Updated: Sep 3, 2025

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

425
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
06:41

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

12.6K
Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
09:47

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

685

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is crucial for refractory cardiogenic shock and cardiac arrest.
  • VA-ECMO significantly impacts arterial oxygenation, presenting complex management challenges.
  • Current guidelines recommend a postoxygenator partial pressure of oxygen (PPOSTO2) target of approximately 150 mmHg.

Purpose of the Study:

  • To review the rationale and evidence supporting the PPOSTO2 target of 150 mmHg during peripheral VA-ECMO.
  • To discuss the complexities of oxygenation management in VA-ECMO patients.
  • To explore the challenges in setting sweep gas oxygen fraction (FSO2) and monitoring oxygenation.

Main Methods:

  • Narrative review of existing literature on VA-ECMO and oxygenation.
  • Focus on peripheral VA-ECMO configurations.
  • Analysis of data regarding oxygenation, hyperoxemia, and mortality in VA-ECMO patients.

Main Results:

  • VA-ECMO frequently leads to arterial hyperoxemia due to oxygenator performance.
  • Dual circulation in VA-ECMO results in heterogeneous oxygen levels within the aorta.
  • Observational studies suggest an association between hyperoxemia and increased mortality, particularly after cardiac arrest.

Conclusions:

  • The PPOSTO2 target of 150 mmHg is based on limited evidence but aims to prevent both hypoxemia and severe hyperoxemia.
  • Optimal FSO2 settings remain unclear, and continuous monitoring is not widely available.
  • Further research is needed to refine oxygenation targets and management strategies during VA-ECMO.