Does Maternal Obesity Affect Preterm Birth? Documentary Cohort Study of Preterm in Firstborns-Silesia (Poland)
Karolina Sobczyk1, Tomasz Holecki1, Joanna Woźniak-Holecka2
1Department of Health Economics and Health Management, School of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41902 Bytom, Poland.
Insights
Maternal obesity significantly increases the risk of preterm birth, particularly extremely and very preterm deliveries. This highlights the importance of pre-pregnancy weight management for reducing adverse birth outcomes.
Area of Science:
- Obstetrics and Gynecology
- Neonatology
- Public Health
Background:
- Preterm birth is a significant challenge in neonatology, with multifactorial causes.
- Maternal obesity is increasingly recognized as a key risk factor for preterm delivery.
Purpose of the Study:
- To investigate the association between pre-pregnancy Body Mass Index (BMI) and the risk of preterm delivery.
- To analyze the risk of preterm birth across different gestational age categories in relation to maternal BMI.
Main Methods:
- A cohort study involving 2794 firstborns.
- Classification of deliveries into extremely preterm, very preterm, and moderately preterm categories.
- Analysis of preterm delivery rates based on maternal BMI (normal weight vs. overweight/obese).
Main Results:
- Preterm deliveries constituted 9.1% of all births.
- The risk of extremely, very, and moderately preterm deliveries escalated with increasing maternal BMI.
- Overweight and obese women (BMI ≥ 25) had a higher incidence of preterm delivery (10.3%) compared to normal-weight women (8%).
- The adjusted odds ratio for preterm delivery in overweight and obese women was 1.33 (95% CI: 0.98-1.79).
Conclusions:
- Maternal overweight and obesity during early pregnancy are linked to an elevated risk of preterm birth in Poland.
- The association is particularly pronounced for extremely and very preterm deliveries.
- Further research is recommended to validate these findings in diverse populations.
Abstract:
In addition to low birth weight and intrauterine growth restriction, prematurity is a major problem in modern neonatology. The etiology of premature delivery is multifactorial, but maternal obesity has been indicated as an important risk factor for preterm birth. This study aimed to assess the relationship between early pregnancy body mass index (BMI) and the risk of preterm delivery according to gestational age. In the cohort of 2794 firstborns, preterm deliveries accounted for 9.1%. Of all deliveries, 16, 48, and 189 were classified as extremely preterm, very preterm, and moderately preterm deliveries, respectively. The risk of extremely, very, and moderately preterm deliveries increased with the increasing BMI, with the highest overweight and obesity-related risk for extremely and very preterm delivery. The rate of extremely and very preterm delivery among normal-weight women (BMI 18.5 ≤ 25) was 1.8%, while that among overweight and obese women (BMI ≥ 25) was 2.36%. The rate of all preterm deliveries (22 ≤ 37 weeks) was 8% for normal-weight women and 10.3% for overweight and obese women. Compared with normal-weight women, the adjusted odds ratio (95% CI) for preterm delivery in overweight and obese women was 1.33 (0.98-1.79). In Poland, being overweight and obese during pregnancy was associated with an increased risk of preterm delivery, especially extremely and very preterm delivery. This relationship should be assessed in other populations.
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